• Making safety part of drug design - Richard Knight, Apconix
  • How to get your molecule into humans: A practical guide for the present and a look to the future - Pauline Garner, Sequani
  • Challenges and opportunities of complex cell models in toxicity testing - Malcolm Haddrick, MDC

2pm BST, 10th June 2020

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Target Validation and Efficacy
2pm BST, Wednesday 3rd June 2020

  • Strategies for target and pathway engagement in cellular assays - Matt Burnham, MDC
  • Go native… Characterising therapeutic effect in primary cellular models - Amanda Woodrooffe, Precision for Medicine
  • Use of pre-clinical models to deliver proof of concept efficacy - Lorraine Mooney, Sygnature Discovery

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Developing a Biomarker Strategy
2pm BST, Wednesday 17th June 2020

  • Designing a biomarker strategy - Gayle Marshall, MDC
  • The challenges of accessing clinical samples - Helen Hind, MDC
  • Biomarker identification: Assessing immune function - Russell Garland, Charles River Laboratories

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About the presenters

Pauline Garner 

Pauline started her career in non-clinical 23 years ago working in the Genetic Toxicology department at Sequani as a Study Director and latterly managing the team. Then in 2012, she made the transition to the Business Development department at Sequani. In her current role as a Programme Manager, Pauline manages the programmes of work that are placed at Sequani, encompassing General, Reproductive, Juvenile and Genetic Toxicology, as well as all supporting scientific disciplines such as Analytical Chemistry, Bioanalysis, Clinical Pathology and Pathology. Sequani Limited is a Contract Research Organisation in Ledbury offering non-clinical expertise and support throughout the development of a pharmaceutical, crop protection product or chemical.